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KMID : 0360320010330060474
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Journal of Korean Cancer Research Association
2001 Volume.33 No. 6 p.474 ~ p.477
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Clinical Features of Neuroendocrine Lung Cancer
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김은경/Eun Kyoung Kim
장근두/서철원/김상위/이상도/김우성/이정신/이호정/이인철/Guun Doo Jang/Cheol Won Suh/Sang We Kim/Sang Do Lee/Woo Seong Kim/Jung Shin Lee/Ho Jung Lee/In Cheol Lee
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Abstract
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URPOSE:
This study was performed to investigate the clinical features of neuroendocrine lung cancer.
MATERIALS AND METHODS:
We performed a retrospective review of the histopathology and clinical information of 21 patients diagnosed as having neuroendocrine lung cancer between 1995 and 1999.
RESULTS:
Nineteen cases were male and 2 were female. The median age was 64 years (range: 45~80). Pathologic classification were atypical carcinoid (AC) in 2 cases, large cell neuroendocrine carcinoma (LCNEC) in 7 cases, and intermediate cell neuroendocrine carcinoma (ICNC) in 12 cases. Nine patients received tumor resection as first line therapy; adjuvant chemotherapy was given to 3 patients. Concurrent chemoradiotherapy was given to 1 patient. Six patients received palliative chemotherapy. The chemotherapy regimen included etoposide cisplatin in 5 cases and vinorelbine+cisplatin in 1 case. The median survival times were 11, 16 and 59 weeks for AC, LCNEC and ICNC, respectively. The estimated 2-year survival rates were AC 0%, LCNEC 22% and ICNC 31%.
CONCLUSION:
Surgery may have a positive effect on survival in patients with early stage cansers. Further investigation is required to improve survival in cases of advanced stage cancer.
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KEYWORD
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Neuroendocrine lung neoplasm,
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